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Willow / Salix alba

Salix alba
Cortex Salicis

Phenolic Content, Antioxidant, Antimicrobial and Cytotoxic Activities of Ethanolic Extract of Salix alba

The total phenolic content, antioxidant, antimicrobial and cytotoxic activities of hot ethanolic extract of Salix alba bark were investigated. The antioxidant properties and the total phenolic contents of the extract were assessed by 1, 1-Diphenyl- 2-Picrylhydrazyl (DPPH) free radical scavenging and FolinCiocalteu methods, respectively. The extract showed significant antioxidant activity and antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The highest effect was observed on C. albicans, followed by S. aureus then P. aeruginosa. While, Escherichia coli and Klebsiella pneumoniae were not affected. The cytoxicity of S. alba extract against the Human Leukemia (HL-60) cell line was evaluated, it had been noticed that the extract significantly reduced the viability of HL-60 cells in a dose- and time-dependent response relationship. Findings from the present study indicate that extract is highly cytotoxic to HL-60 cells. The antimicrobial and cytotoxic activities of S. alba extract seemed to be positively correlated with their antioxidant potentials.

Keywords: Phenolics, Antioxidant, Antimicrobial, Cytotoxicity

More information: http://thescipub.com/pdf/10.3844/ajbbsp.2013.41.46



Introduction: Many specialists in pain management view the integration of traditional treatment approaches and a wide range of complementary and alternative medicine approaches as the ideal goal of many types of pain. Pain is a subjective, complex, multidimensional and unpleasant experience. It is one of the most prevalent conditions that require medical attention. Nowadays the number of patients that are using herbal remedies and complementary and alternative medicine for treatment of pain is growing rapidly. Objectives: The aim of this investigation is to describe the concept of complementary and alternative medicine – CAM and the role of specific plants and their anti-inflammatory activity in curing inflammatory painful diseases. Conclusions: Nonsteroidal anti-inflammatory drugs and opioid analgesics are normally used to treat inflammation and pain, but they can manifest a great number of adverse effects. Therefore herbal drugs can be a potential source to replace them. Many medicinal plants, some of them indigenous, are known for their analgesic and anti-inflammatory effect, but only a few are included in the health care system after clinical research. So, it is time to give an important place to the scientific uses of natural medicinal plants and investigation of the active phytoconstituents of them. Extraction of the active principle of herbal drugs and their pharmaceutical formulation must be the main direction of industrial research.

Keywords: Anti-inflammatory, complementary and alternative medicine, herbal drug, inflammation, pain

More information: https://eujournal.org/index.php/esj/article/viewFile/908/950

Willow monograph


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