COMPARATIVE EFFICACY OF NEEM (AZADIRACHTA INDICA) AND METFORMIN HYDROCHLORIDE (COMET®) IN STREPTOZOTOCIN INDUCED DIABETES MELITUS IN RATS
The present study was investigated the comparative efficacy of extract of Neem (Azadirachta indica) and Metformin hydrochloride (Comet®) in respect of their hypoglycemic activity in Streptozotocin (STZ)-induced diabetic rats. Extract of Neem was administered @ 500 mg/kg body-weight (bwt) and 250 mg/kg bwt. Metformin hydrochloride @ 500 mg/kg bwt and 250 mg/kg daily orally for 21 days. Changes in the blood glucose level and body weight were measured and the results were compared statistically using Anova test. The extract of Neem leaves and Metformin hydrochloride showed significant (p<0.01) hypoglycemic effect and neem extracts at 250 mg/kg bwt showed more potent effects. The Neem extracts significantly (p><0.01) increased body weight @ 250 mg/kg. From this experiment it was observed that extracts of Neem leaves had hypoglycemic and body weight gain effect. For definite conclusion, details study is needed. Key words: Diabetes mellitus hypoglycemia, body weight, blood glucose, Azadirachta Indica, metforminhydrochloride and Streptozotocin >< 0.01) hypoglycemic effect and neem extracts at 250 mg/kg bwt showed more potent effects. The Neem extracts significantly (p<0.01) increased body weight @ 250 mg/kg. From this experiment it was observed that extracts of Neem leaves had hypoglycemic and body weight gain effect. For definite conclusion, details study is needed.
Key words: Diabetes mellitus hypoglycemia, body weight, blood glucose, Azadirachta Indica, metforminhydrochloride and Streptozotocin
More information: https://www.banglajol.info/index.php/BJVM/article/viewFile/8353/6190
Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides
Over the years, extensive use of commercially available synthetic pesticides against phytophagous insects has led to their bioaccumulation in the environment causing increased resistance and reduction in soil biodiversity.
Further, 90% of the applied pesticides enter the various environmental resources as a result of run-off, exposing the farmers as well as consumers of the agricultural produce to severe health issues.
Therefore, growing attention has been given toward the development of alternate environmentally friendly pesticides/insecticides that would aid an efficient pest management system and also prevent chronic exposures leading to diseases.
One such strategy is, the use of neem plant’s (Binomial name: Azadirachta indica) active ingredients which exhibit agro-medicinal properties conferring insecticidal as well as immunomodulatory and anti-cancer properties.
The most prominent constituent of neem is azadirachtin, which has been established as a pivotal insecticidal ingredient. It acts as an antifeedant, repellent, and repugnant agent and induces sterility in insects by preventing oviposition and interrupting sperm production in males.
This review discusses, key neem pesticidal components, their active functional ingredients along with recent strategies on employing nanocarriers, to provide controlled release of the active ingredients and to improve their stability and sustainability.
Keywords: azadirachtin, pesticides, biopesticide, Azadirachta indica, agro-medicinal components, nanocarriers, sustained delivery