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Milk thistle / Carduus marianus

Carduus marianus
Fructus Silybi Mariae

Silymarin, A Promising Nature’s Remedy for Liver Diseases

Submission: March 20, 2017

Published: August 21, 2018

Chronic liver diseases remains as one of the most serious health problems worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis,and hepatocellular carcinoma. Since ancient times herbal medicines have been used for various diseases. In the recent decades an increasing number of herbal products, including medicinal herbs and phytochemicals, have been used for treating a variety of diseases worldwide. Thereby, numerous medicinal herbs and phytochemicals have been used as complementary and alternative treatments for chronic liver diseases. Thus, the present review explores the current knowledge of the herbal medicine silymarin in treating chronic liver diseases and on its flaws which need to be overcome in future studies.

Keywords: Liver; Cirrhosis; Silymarin; Hepatocellular carcinoma; herbal medicines; Hepatitis

More information: https://juniperpublishers.com/jcmah/pdf/JCMAH.MS.ID.555704.pdf


Characterization of Silybum marianum triacylglycerol regioisomers using accurate mass quadrupole time of flight mass spectrometry


Milk thistle (Silybum marianum) is a medicinal plant commonly used as a food supplement for liver protection against hepatitis C virus. The fruits are very rich in lipids (>30%); however, their chemical structures are not well characterized. In this investigation, dry fruits were extracted using CO2 supercritical fluid extraction to obtain the crude lipid components. Triacylglycerols (TAGs) were isolated from the crude lipid extract using high-performance thin layer chromatography. Fatty acid composition of the purified TAGs was identified as their fatty acids methyl esters (FAMES) using gas chromatography mass spectrometry. Regioisomers of TAGs and their relative abundances were determined using accurate mass ultra-high-performance liquid chromatography quadrupole time of flight mass spectrometry both in the full scan and in MSMS electrospray ionization modes. Major identified fatty acids were 18:2, 18:1 and 16:0. Twenty-six different TAGs were identified with LLL, OLL, PLL, LOO and PLO as the major components. Subjects: Analytical Chemistry; Natural Products; Chemical Spectroscopy

Keywords: milk thistle; QTOF; lipids; fatty acids; medicinal plants; liver protection; complementary alternative medicine (CAM)

More information: https://www.cogentoa.com/article/10.1080/23312009.2018.1477246.pdf

Milk thistle Monograph

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