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Angelica / Angelica archangelica

Angelica archangelica
Radix Angelicae Sinensis


A Clinical Research of The Effect of Ferulic Acid and Angelica Archangelica Extract on Amyloid Beta Deposition in Mild Cognitive Impairment Patients.

The objective is to assess the effect of ferulic acid and angelica archangelica on amyloid beta deposition in MCI patients’brain and to examine their clinical benefit.

  • Primary outcome The time-depending change of [11C]PiB amyloid positron emission tomography tracer bindings in MCI patients’ brain at baseline, 48 weeks, and 96 weeks after taking the supplement.
  • Secondary outcomes
    1. The time-depending change of magnetic resonance imaging of the brain at baseline, 48 weeks, and 96 weeks after taking the supplement.
  1. The time-depending change of psychological test score with time, at baseline, 24 weeks, 48 weeks, 72 weeks and 96 weeks after taking the supplement.

Design of the research

  • This is a open-label interventional multi-institutional joint research of Kobe University and Institute of Biomedical Research and Innovation (IBRI).
  • Research Period
    Recruitment:from August 2014 to March 2017
    Total research period:from August 2014 to March 2020
  • Subjects
    Twenty patients diagnosed as MCI
    Intervention group(taking the supplement):10 patients
    Control group(not taking the supplement):10 patients
    Each subject decides which group he joins according to his will.

Amyloid negative subject in the screening test is ineligible.


More information: https://www.alz.co.uk/sites/default/files/conf2017/o21-05-kenichi-matsuyama-ferulic-acid-and-angelica-archangelica-extract-amyloid-beta-deposition.pdf

Angelica monograph


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