- Clinical data 90%
- Efficacy 80%
- Security 80%
- Toxicity 20%
Mimosa cabrera, Mimosa hostilis, Mimosa limana, Mimosa nigra, Mimosa tenuiflora
Major chemical constituents
It contains abundant condensed tannins (12%) and a group of saponins: triterpene glycosides (mimosides A and B), and triterpenoid mimonoside C, in addition to three steroid saponins (3-O-β-D-glucopyranosyl campesterol, 3-O- β-D-glucopyranosyl stigmasterol, 3-O-β-D-glucopyranosyl β-sitosterol) together with trace concentrations of glucose, xylose, rhamnose, arabinose and lupeol. It has been reported to contain a low amount of alkaloids derived from tryptamine, mainly N, N-dimethyltryptamine present in 0.003% and also contains serotonin in 0.001%.
Medicinal uses of Mimosa tenuiflora
Traditionally, dried and powdered Mimosa tenuiflora bark is used to treat burns and skin wounds.
In the clinic, the healing effect of a preparation in the form of a gel based on an extract standardized in its content of condensed tannins and administered topically in patients with varicose ulcers was evaluated.
The healing properties of the bark of tepescohuite are due to a set of antimicrobial-type effects, to a stimulation in the proliferation of fibroblasts and their immunomodulatory effect.
The extracts of the bark of Mimosa tenuiflora, especially the aqueous and ethanolic extract, have antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli, as well as those that are usually found on the skin and are potentially pathogenic: Klebsiella pneumoniae, Micrococcus luteus, Staphylococcus epidermidis, Proteus vulgaris, Acinetobacter calcoaceticus, and Candida albicans, Trychophyton mentagrophytes, Trycophyton rubrum, Microsporum canis and Microsporum gypseum. The responsible for inhibiting bacterial growth are the ellagitannins, major compounds in tepescohuite extracts. Recently, an ethanolic extract of the bark was evaluated on the pathogenic flora obtained from decubitus ulcers, with an antimicrobial effect against Enterobacter aerogenes, Providence sp., Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella sp.
It has been shown through in vitro studies with cell cultures and markers of cell proliferation (triatal thymidine) that saponins isolated from the bark of M. tenuiflora increase the proliferation of fibroblasts and lymphocytes. They produce a synergistic immunostimulant effect of mimonosides and polysaccharides, activating mouse thymocytes and splenocytes; as well as cytotrophic properties in cultures of mouse and human fibroblasts. It should be noted that it has been reported that the fraction of mimonosides does not have cytotoxic activity on lymphoma cells (Molt 4 and RDM 4). These results explain the possible mechanism involved in the traditional use of this medicinal species as a healing agent.
In the clinic, the standardized extract was evaluated in its tannin content in patients with lower limb venous ulcers compared with conventional treatment (wound washing, debridement and bandaging). A significant improvement was observed in favor of the extract with an average reduction of 93% at the end of the treatment, without reporting adverse events and with good therapeutic tolerability.
It can cause contact dermatitis.