• Clinical data 90%
  • Efficacy 80%
  • Security 65%
  • Toxicity 35%

Ruta graveolens


Ruda angustifolia, Ruda chalepensis, Ruda montana, Ruta graveolens.

Major chemical constituents

– Essential oil (0.1%), rich in methylnonyl ketone and furanocoumarins (psoralen, bergapten, xantotoxin).
-Heterósidos: routine (1-2%), cnidiósido, picracusiósido, 3 ‘, 6-disinapolisacarosa, metiopicraquasiósido, metilcnidiósido, 3’-sinapoil-6-feruloilsacarosa.
-Alcaloids: arborinin, rutamin, graveolinin, graveolin, furoquinoline, T-fagarine, etc.

Medicinal uses of Ruta graveolens

The therapeutic use of rue is not recommended, because its efficacy has not been proven and the risk involved.

Posology / method of use

Internal use (see sections: side effects and precautions):
– Infusion at 1%, one or two cups a day.
– Powder: 250 to 500 mg / day, in capsules of 50 g.
– Essential oil: 2 drops a day, in a sugar cube, or in an oily or alcoholic solution.
– Fluid extract (1: 1): 10-30 drops, one to three times a day.
– Tincture (1:10): 30-50 drops, two or three times a day.
External use:
– Infusion: 2 to 5 g / l, applied in the form of compresses or washes.


The routine gives it venotonic and vasoprotective properties.
The hydrous ethanol extract has a dose-dependent analgesic effect in mice due to both peripheral and central action. This same extract shows anti-inflammatory activity only against chronic inflammations, a fact related to an antiproliferative effect. The methanolic extract possesses antibacterial activity against Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, bacteriostatic against Bacillus subtilis, and is inactive against Escherichia coli, Candida albicans, Saccharomyces cerevisiae and Aspergillus niger. It also has antifungal activity against Fusarium culmorum, Heterobasidion annosum and Rhizoctonia solani and has no activity on Botrytis cinerea and Phytophora cactorum. These activities would be related to essential oil components and flavonoids. In addition, the essential oil is vermifuge, in external use, and rubefaciente.
The acaloides rutamin, T-fagarine, and furoquinoline and the essential oil, show spasmolytic activity on the smooth muscle. Furocoumarins have antihistamine and anti-inflammatory activity.
Different extracts of rue show inhibitory effect on spermatogenesis and post-coital abortive effect in vivo, after oral administration.


See the precautions and toxicity section.

Side effects

See the precautions and toxicity section.


Poisoning: gastroenteritis, tongue and pharyngeal swelling, sialorrhea, excitement followed by depression, dizziness, mental confusion, tremors, convulsions, metrorrhagia, nephritis, liver and small bowel injuries and even death from cardiorespiratory depression.
Methylnonyl ketone contained in the essence has a stimulating effect, in vitro, on the uterine muscle fiber, so it can be abortive. Its use as an abortifacient is highly dangerous, since the action occurs at doses very close to the toxic ones.
Furocoumarins are photosensitizing compounds, therefore it is necessary to avoid sun exposure after topical application, to avoid the appearance of photosensitization dermatitis.
The fresh plant can generate contact dermatitis.

More information: https://www.fitoterapia.net/vademecum/plantas/index.html?planta=139&tipo_nombre=1

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