- Clinical data 90%
- Efficacy 80%
- Security 80%
- Toxicity 20%
It has a complex chemical composition with more than 400 compounds identified, among which three mainly phytochemical groups stand out: polysaccharides (45%), triterpenoids and ergosterol. Among the polysaccharides (β-D-glucans), 3 ganoderans (A, B and C), two heteroglycans (PL-1 and PL-2) and one homoglycan (PL-3) have been described; more than 80 terpenoids (ganodéricos acids, ganoderioles, lanosteroles, ganolucídicos and lucidénicos acids) and diverse steroids derived from ergosterol. Other compounds have also been isolated such as lectins (glycoproteins), nucleotides (adenosine analogs), fatty acids, peptides and minerals.
Medicinal uses of Ganoderma lucidum
It is used mainly in acute and chronic hepatitis, and liver cirrhosis. It is recommended as a coadjuvant in the prevention and treatment of oncological processes, hypertension, hyperlipidemia, arteriosclerosis, prevention of thromboembolism, post-herpetic neuralgia and diabetes. It is also used in the background treatment of asthenia and allergic processes, osteoarticular inflammations, myalgias, muscular contractures and immunodeficiencies induced by opioid abuse.
Studies of reishi products in cancer have been carried out mainly in patients with lung carcinoma and for the prevention of colorectal cancer. In the latest Cochrane review on reishi in cancer treatment (Yi et al.), The authors conclude that there is insufficient evidence to justify its use as a first-line treatment for cancer, as it is not sufficiently proven if it helps to prolong Long-term cancer survival. However, considering its potential to enhance the tumor response and stimulate host immunity, together with the absence of toxicity and adverse effects, suggest that it could be administered as a complement to conventional treatment. The authors recommend carrying out more studies, methodologically adequate, in the long term.
Several studies have shown that polysaccharides have immunostimulatory properties (favor the proliferation of B and T lymphocytes, and increase the activity of the latter), anticancer drugs (stimulates production of antitumor cytokines and protect DNA breakage) and antioxidants (decrease oxidation of cholesterol- LDL). The glycoproteins inhibit the replication of the herpes simplex virus (HSV).
Triterpenes increase cytotoxicity and induce apoptosis (anticancer), are hepatoprotective (reduce the levels of aspartate transaminase, alanine transaminase, lactodehydrogenase, alkaline phosphatases and total bilirubin), inhibit histamine release (anti-allergic and anti-inflammatory), decrease the absorption and synthesis of cholesterol (hypocholesterolemic), inhibit platelet aggregation (anticoagulant) and protease activity HIV-1 (anti-AIDS). Analgesic, hypoglycaemic (antidiabetic), muscle relaxant (spasmolytic) and angiotensin converting enzyme (antihypertensive) inhibitors have also been described.
Initial decompensation of blood glucose can occur, which usually normalizes after a few weeks.
When prescribing diabetic patients, the doctor should control the glucose levels and adjust the doses of insulin or oral antidiabetics if necessary.