• Clinical data 90%
  • Efficacy 90%
  • Security 90%
  • Toxicity 10%

Rhodiola rosea

Radix Rhodiolae


Sedum roseum

Major chemical constituents

Phenylpropanoids (rosavin, rosin and rosarin, included under the common name of rosarines), derivatives of phenylethanol (salidrósido or rodiolósido and tyrosol), flavonoids (rhodionine, rhodosine, acetyldalgina and tricine) and monoterpenes. Most of the extracts used in clinical studies are standardized in 3% of rosavins and 0.8-1% of salidroside.

Medicinal uses of Rhodiola rosea

The European Medicines Agency (EMA) accepts its traditional use for the relief of symptoms of asthenia, such as fatigue and weakness.

Most clinical studies refer to their effectiveness on physical and cognitive function, at different levels:

– Improvement of physical and mental performance in situations of fatigue, as well as the ability to work: reduces the severity of fatigue after the practice of intense physical exercise, reduces the recovery period and improves the circulatory adaptation to exercise (pulse and pressure blood).

– Effect on depression and anxiety: it produces an improvement in the symptoms of depression according to the Hamilton scale for depression (HAMD) and reduces anxiety levels in the Hamilton anxiety scale (HARS).

– Increased visual perception, short-term memory and attention. In clinical trials it has been observed that it produces an improvement, in a dose-dependent manner, in all the parameters studied: exhaustion, decreased motivation, drowsiness, decreased libido, sleep disorders and cognitive deficiency.


Numerous pharmacological actions have been described for Rhodiola rosea preparations, highlighting the following effects: adaptogen (concept related to the ability to normalize body functions and strengthen systems compromised by stress), cell protector, antidepressant and anxiolytic, antioxidant, anti-inflammatory and immunomodulator.

The term “adaptogen” was originally established by N. V. Lazarev (1947) to refer to substances that, in a non-specific manner, increase the body’s resistance to stress and a wide spectrum of adverse biological, chemical and physical factors. At present it is considered an imprecise term. The drugs considered adaptogenic tend to present some of the following activities: general tonic (increase the feeling of general well-being and work capacity), antioxidant, anticancer, immunomodulatory, lipid-lowering and hypoglycemic.


The safety of its use in pregnancy, lactation and children has not been established.


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