- Clinical data 90%
- Efficacy 80%
- Security 70%
- Toxicity 30%
Ginger Zingiber officinale
Amomum zingiber L. (1, 6), Zingiber blancoi Massk.
Ginger occurs in horizontal, laterally flattened, irregularly branching pieces; 3–16cm long, 3–4cm wide, up to 2 cm thick; sometimes split longitudinally; pale yellowish buff or light brown externally, longitudinally striated, somewhat fibrous; branches known as “fingers” arise obliquely from the rhizomes, are flattish, obovate, short, about 1–3cm long; fracture, short and starchy with projecting fibres. Internally, yellowish brown, showing a yellow endodermis separating the narrow cortex from the wide stele, and numerous scattered fibrovascular bundles, abundant scattered oleoresin cells with yellow contents and numerous larger greyish points, vascular bundles, scattered on the whole surface.
Major chemical constituents
The rhizome contains 1–4% essential oil and an oleoresin. The composition of the essential oil varies as a function of geographical origin, but the chief constituent sesquiterpene hydrocarbons (responsible for the aroma) seem to remain constant. These compounds include (-) zingiberene, (+)-ar-curcumene, (-)--sesquiphellandrene, and -bisabolene. Monoterpene aldehydes and alcohols are also present. The constituents responsible for the pungent taste of the drug and possibly part of its anti-emetic properties have been identified as 1-(3- methoxy-4-hydroxyphenyl)-5-hydroxyalkan-3-ones, known as [3–6]-, -, -, and -gingerols (having a side-chain with 7–10, 12, 14, or 16 carbon atoms, respectively) and their corresponding dehydration products, which are known as shogaols.
Uses supported by clinical data
The prophylaxis of nausea and vomiting associated with motion sickness, postoperative nausea, pernicious vomiting in pregnancy, and seasickness.
Uses described in pharmacopoeias and in traditional systems of medicine
The treatment of dyspepsia, flatulence, colic, vomiting, diarrhoea, spasms, and other stomach complaints. Powdered ginger is further employed in the treatment of colds and flu, to stimulate the appetite, as a narcotic antagonist, and as an anti inflammatory agent in the treatment of migraine headache and rheumatic and muscular disorders.
Uses described in folk medicine, not supported by experimental or clinical data
To treat cataracts, toothache, insomnia, baldness, and haemorrhoids, and to increase longevity.
Intraduodenal administration of an acetone extract (mainly essential oils) of ginger root to rats increased bile secretion for 3 hours after dosing, while the aqueous extract was not active. The active constituents of the essential oil were identified as - and -gingerol. Oral administration of an acetone extract of ginger (75 mg/kg), -shogaol (2.5 mg/kg), or -, -, or -gingerol enhanced gastrointestinal motility in mice, and the activity was comparable to or slightly weaker than that of metoclopramide (10mg/kg) and domperidone. The -, -, or - gingerols are reported to have antiserotoninergic activity, and it has been suggested that the effects of ginger on gastrointestinal motility may be due to this activity. The mode of administration appears to play a critical role in studies on gastrointestinal motility. For example, both -gingerol and - shogaol inhibited intestinal motility when administered intravenously but accentuated gastrointestinal motility after oral administration.
The emetic action of the peripherally acting agent copper sulfate was inhibited in dogs given an intragastric dose of ginger extract, but emesis in pigeons treated with centrally acting emetics such as apomorphine and digitalis could not be inhibited by a ginger extract. These results suggest that ginger’s antiemetic activity is peripheral and does not involve the central nervous system. The antiemetic action of ginger has been attributed to the combined action of zingerones and shogaols.
One of the mechanisms of inflammation is increased oxygenation of arachidonic acid, which is metabolized by cyclooxygenase and 5 lipoxygenase, leading to prostaglandin E2 and leukotriene B4, two potent mediators of inflammation. In vitro studies have demonstrated that a hot-water extract of ginger inhibited the activities of cyclooxygenase and lipoxygenase in the arachidonic acid cascade; thus its anti-inflammatory effects may be due to a decrease in the formation of prostaglandins and leukotrienes. The drug was also a potent inhibitor of thromboxane synthase, and raised prostacyclin levels without a concomitant rise in prostaglandins E2 or F2α. In vivo studies have shown that oral administration of ginger extracts decreased rat paw oedema. The potency of the extracts was comparable to that of acetylsalicylic acid. - Shogaol inhibited carrageenin-induced paw oedema in rats by inhibiting cyclooxygenase activity. Recently, two labdane-type diterpene dialdehydes isolated from ginger extracts have been shown to be inhibitors of human 5- lipoxygenase in vitro.
Antinausea and antiemetic activities
Clinical studies have demonstrated that oral administration of powdered gingerroot (940 mg) was more effective than dimenhydrinate (100 mg) in preventing the gastrointestinal symptoms of kinetosis (motion sickness). The results of this study further suggested that ginger did not act centrally on the vomiting centre, but had a direct effect on the gastrointestinal tract through its aromatic, carminative, and absorbent properties, by increasing gastric motility and adsorption of toxins and acids.
In clinical double-blind randomized studies, the effect of powdered ginger root was tested as a prophylactic treatment for seasickness.
The results of one study demonstrated that orally administered ginger was statistically better than a placebo in decreasing the incidence of vomiting and cold sweating 4 hours after ingestion. The other investigation compared the effects of seven over-the-counter and prescription antiemetic drugs on prevention of seasickness in 1489 subjects. This study concluded that ginger was as effective as the other antiemetic drugs tested.
At least eight clinical studies have assessed the effects of ginger root on the symptoms of motion sickness. Four of these investigations showed that orally administered ginger root was effective for prophylactic therapy of nausea and vomiting. The other three studies showed that ginger was no more effective than a placebo in treating motion sickness. The conflicting results appear to be a function of the focus of these studies. Clinical studies that focused on the gastrointestinal reactions involved in motion sickness recorded better responses than those studies that concentrated primarily on responses involving the central nervous system.
The hypothesis that an increase in gastric emptying may be involved in the antiemetic effects of ginger has recently come under scrutiny. Two clinical studies demonstrated that oral doses of ginger did not affect the gastric emptying rate, as measured by sequential gastric scintigraphy or the paracetamol absorption technique.
In a double-blind, randomized, cross-over trial, oral administration of powdered ginger (250 mg, 4 times daily) effectively treated pernicious vomiting in pregnancy. Both the degree of nausea and the number of vomiting attacks were significantly reduced. Furthermore, in a prospective, randomized, double-blind study, there were statistically significantly fewer cases of postoperative nausea and vomiting in 60 patients receiving ginger compared to a placebo. The effect of ginger on postoperative nausea and vomiting was reported to be as good as or better than that of metoclopramide. In contrast, another double-blind randomized study concluded that orally administered ginger BP (prepared according to the British Pharmacopoeia) was ineffective in reducing the incidence of postoperative nausea and vomiting.
One study in China reported that 113 patients with rheumatic pain and chronic lower back pain, injected with a 5–10% ginger extract into the painful points or reaction nodules, experienced full or partial relief of pain, decrease in joint swelling, and improvement or recovery in joint function. Oral administration of powdered ginger to patients with rheumatism and musculoskeletal disorders has been reported to provide varying degrees of relief from pain and swelling.
No information available.
No information available.
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