- Clinical data 70%
- Efficacy 80%
- Security 95%
- Toxicity 5%
Juliania adstringens Schlechter
Tree 10 m tall, with the twisted trunk of grayish brown bark or gray lead with large scales. The leaves are grouped in the tips of the branches in number of three to five, in the obverse they are green opaque and in the back greenish gray. The flowers can be solitary or in bouquets. The fruits are bulky and elongated walnuts that are in pale green branches.
Of unknown origin, this species lives in warm, semi-warm and temperate climate from 100 and 3000 meters above sea level. It grows in disturbed areas of deciduous and sub-deciduous tropical forest, xerophilous scrub, thorny forest, mountain mesophyll and pine-oak.
Major chemical constituents
All chemical research on this plant has been done in Mexico. Acid triterpenes 3-alpha and 3-epi-masticadienóico, isomasticadienóico and epi-oleanólico have been identified in the bark of the stem; the benzyl acid compounds 6-heptadecyl-, 6-nonadecyl-, and 6-pentadecylsalicylic; and the sterol, beta-sitosterol. In the leaf has been identified cuachalálico acid that is a triterpeno.
From the bark of this plant have been isolated the instinolytic, oleanolic, chewing-gum, and 3-alpha-hydroxy-masticadienonic acid triterpenes, a mixture of anacardic acids, and phenolic aldehydes.
The masticadienonic and 3-alpha-hydroxy-masticadienonic acids exerted a hypocholesterolemic effect in rats subcutaneously at a dose of 17 mg / g. Blood cholesterol was measured 24 hours after injection and an average decrease of 34mg / 100ml and 19mg / 100ml, 45% and 27% respectively was obtained.
A triterpene isolated from the plant of unidentified structure, presented an anti-ulcer action in rats orally, equal to or better than that effected by emetidine and atropine.
Medicinal uses of Amphypteringium adstringens
In several states of the republic the use of Amphypteringium adstringens, mainly of cooking, is frequently mentioned to treat ulcers, stomach cancer, gastritis and certain cutaneous lesions. In the treatment of ulcers, an aqueous maceration of the bark is also administered as water for use, until the water acquires color.
In order to alleviate the wounds, it is cooked and powdered on them, or it is washed locally with a macerated bark in water. Grains and sores are cured by ingestion of cooking or application of white gum or bark resin. Grains, wounds and sores, in man or animals, are washed once a day with water where the “shell” has been boiled (only until the water is painted) and it is also sprayed on the affected part, three times a day. day. Baby chafing is washed once daily for five days. Likewise, it is used in blows or postemas, bites or pickets of poisonous animals and as a cicatrizant.
This same decoction of the cortex is taken or applied in fomentations on tumors or “cancer”. It is used in vaginal washes when there are infections in the vagina, puerperal fever, women’s flow, cold, inflammation, infection or fall of the womb and fall of ovaries. If there are grains in the genitals, with the cooking of conteloloache, arnica (sp n / r) and salt, they are washed as many times as necessary (V. purgation). In addition, it is used to treat the cachán or cachans, a disease that according to traditional birth attendants, they contract puerperals as a result of being “cold” inside the body.
On the other hand, it is used in digestive discomforts, stomach pain, infection or intestinal inflammation, to clean the stomach, for the liver, the gallbladder, against typhoid and in oral problems such as toothache, to harden the gums, in cases of stomatitis or fires in the mouth.
It is used to relieve respiratory conditions, cough, inflammation of angina, colds, tuberculosis and lung diseases. For the latter, the peel is boiled, until the water is painted, and it is sweetened four times a day, as long as necessary or drunk as water for use. Likewise, it is prescribed for coughing, although a syrup made with the cuachalalate bark is also recommended, as well as a tripita of cuatecomate, arnica, alcohol, bee honey and sugarcane bagasse, administering a spoonful every hour.
In diseases of the kidney, including pain and inflammation, the bark is cooked three times a day, prepared together with a three-rib stem (V. kidney pain).
It is also used in problems related to blood and its circulation, to purify or detoxify it, to cure varicose veins and ulcers.
It is used as an analgesic in pain in the waist, head, back or lungs (lung pain), hernia, rheumatism or stitches.
Other medicinal applications that are known are: intermittent fevers, malaria, fever, hair loss, skin blemishes, gangrene and as an antidiabetic.
The antitumor activity of a methanolic extract of the plant, administered intramuscularly to mice with mammary tumors, spontaneous carcinomas has been experimentally proven.
A pharmacological investigation in rats kept fasting for 24 hours showed that the subcutaneous administration of the hexane extract of the bark, at a dose of 100mg / kg, induced a significant hypocholesterolemic effect, decreasing cholesterol levels by 31%.
The cooking of the bark and an ethyl acetate extract, administered to rats orally and intraperitoneally, exerted an antiulcerogastric effect, inhibiting the secretion of gastric stomach juice and contributing to the faster healing of the epithelium and gastric mucosa. Contrary to this, another study showed the absence of inhibitory activity of gastric secretion with an aqueous extract at 4 and 8% administered to rats in a single dose and determined the action at 24 hours.
The cuachalalate, Amphipteryngium adstringens, is a plant of very old use of which an antitumor and anticancer activity has been confirmed in certain types of tumors, medicinal use for which it is recommended.
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