- Clinical data 90%
- Efficacy 80%
- Security 100%
- Toxicity 0%
Arctium minus, Arctium lappa, Arctium majus, Arctium tomentosum, Lappa major, Lappa minor
Major chemical constituents
It contains around 70% carbohydrates, mainly inulin (30-50%) and mucilage. Phenolic acids (caffeic, chlorogenic, isoclorogenic acids and caffeic acid derivatives). Lignanolides (arctiin, converted by the intestinal flora in arctigenin), polyacetylenes (trideca-1,11-dien-3,5,7,9-tetraine), sulfur acetylenic compounds (arctic acid, arctinone, arctinol, arctinal). Cosmetic acid. Guayanolide sesquiterpene lactones (dehydrocostulactone and 11,13-dihydrodehydrocostuslactone). Traces of essential oil (phenylacetaldehyde, benzaldehyde, methoxy and methylpyrazines) Polyacetylenes (arctic acid, arctinone, arctinol, arctinal) Phytosterols (β-sitosterol, stigmasterol) Tannins Potassium salts.
Medicinal uses of the Arctium lappa
Indications approved by ESCOP (based on its traditional use):
– Internal use: seborrhoeic dermatitis, ezcema, boils, acne, psoriasis; washing of the urinary tract.
– External use: seborrheic dermatitis, ezcema, boils, acne.
The European Medicines Agency (EMA) approves its traditional use of Arctium lappa to increase urinary flow, as an adjuvant in mild urinary disorders, in temporary loss of appetite and for the treatment of seborrheic states of the skin.
The antimicrobial and antifungal actions attributed to it have been proven in in vitro studies. An extract, obtained with ethyl acetate, has shown antibacterial activity against: Pseudomonas aeruginosa, Escherichia coli, Lactobacillus acidophilus, Streptococcus mutans and Candida albans.
Both arctiin and arctigenin have a potent antiviral action against influenza A (H1N1) virus, in vitro and in vivo after oral administration. No emergence of resistant virus was observed after administration of arctiin. In addition, arctigenin inhibits replication of the AIDS virus (HIV-1) by suppressing the integration of proviral DNA into the genome of the host cell.
The anti-acne effect of the ethanolic extract of burdock root has been demonstrated in vitro, by inhibiting the chemotactic effect of P. acnes on neutrophils, thus interfering with the first steps of the inflammatory process that accompanies acne. In addition, arctigenin significantly inhibits the induction by LPS on: the production of TNFα, both in murine and human macrophages, the activation of the enzyme iNOS in murine macrophages (by suppressing the activation of NF-κB), and the phosphorylation of mitogen-activated protein kinases (MAPKs) ERK1 / 2, p38 and JNK, in murine macrophages.
Arctigenin also attenuates the proliferation of T and B lymphocytes stimulated with concanavalin A, and inhibits the expression, in mammalian cells, of stress proteins (Hsp) induced by thermal stress. The related mechanism of action includes suppression of the transcription factor response, mRNA induction and synthesis and accumulation of Hsp. Arctigenin inhibits, in vitro and in vivo, the growth of prostate cancer cell lines.
The orally administered drug prevents intestinal damage and the release of cytokines in a murine model of ulcerative colitis. Both phenolic acids and arctiin and arctigenin have shown antioxidant activity. Additionally, arctigenin and other metabolites obtained from arctiin by the action of the intestinal flora, have demonstrated estrogenic and antiestrogenic activity.
Known hypersensitivity to plants of the Compositae family (Asteraceae).
They have not been described.