Horse chestnut – efficacy and safety in chronic venous insufficiency: an overview
The extract from horse chestnut seeds (Aesculus hippocastanum L., Sapindaceae), standardised for the content of aescin, is used as the treatment for chronic venous insufficiency. It has anti-inflammatory and anti-oedematous properties and indicates a positive effect on the venous tone, rheological properties, and blood coagulability. The mechanism of horse chestnut seed extract/aescin activity was proposed on the basis of in vitro and in vivo studies, and its effectiveness was documented with numerous randomised clinicaltrials. The results ofthe studies have proven that horse chestnut seed extract not only significantly improves subjective symptoms in patients with chronic venous insufficiency like calf spasm, leg pain, pruritus, fatigue, but it also reduced leg volume, the ankle and calf circumference. The preparations containing horse chestnut seed extract are very popular and they have similar effectiveness as compression therapy and a preparation with O-(-hydroxyethyl)-rutosides. Moreover, horse chestnut seed extract has been proven to be safe and very well tolerated. The study was to present the results of the studies that have been conducted so far and that have confirmed the effectiveness of use of horse chestnut seed extract or aescin as the treatment for chronic venous insufficiency.
More information: http://www.scielo.br/pdf/rbfar/v25n5/0102-695X-rbfar-25-05-0533.pdf
A Review of Medicinal Plants Used in Therapy of Cardiovascular Diseases
Phytochemicals are present in fruits and vegetables, it is important the consumption by the effects in protection of cardiovascular diseases mainly because these diseases are the first cause of death in world. This study is a review of principal phytochemicals present in plants (that are used in meals or not), mainly: Allium cepa; Allium sativa; Citrus limon and Citrus sinensis; Coffea arabica and Coffea liberica; Ginkgo biloba; Digitalis purpurea and Digitalis lanata, between others. The substances in these plants have a therapeutic effect in cardiovascular diseases (CVDs) like as: hypertension, atherosclerosis and stroke, between others. By other side, we can conclude that principal compounds are flavonoids; antioxidants (action in oxidative stress); ouabain; cardenolide glicosides; lanatosides; tannins; sesquiterpenoids and phenolic compounds.
Keywords: cardiovascular diseases (CVDs); hypertension; phytochemicals; cardenolide glicosides; lanatosides; tannins; phenolic compounds.
More information: http://impactfactor.org/PDF/IJPPR/8/IJPPR,Vol8,Issue4,Article6.pdf