Dandelion / Taraxacum officinale

Radix cum Herba Taraxaci

Taraxacum offcinale

Radix cum Herba Taraxaci

The Research of Low- Molecular Protectors in Taraxacum Officinale Wigg. in Connection with Mining Waste Utilization

This paper presents a research on the content of low-molecular metabolites possessing protecting properties (free proline, reducing sugars, succinic acid) in Taraxacum officinale Wigg. which grows on the mining wastes of Kedrovsky open pit in Kemerovo region. The paper also researches the topic of relation between the content of the above substances and morphometric characteristics of the plant such as weight of leaves and roots, length of roots and surface area of leaves. In the course of the research in was established that adverse edaphic effects of mining waste cause adaptive changes of Taraxacum officinale, which affect the plant on biochemical and organ level. As for biochemical level the increase in content of low-molecular protectors in leaves and roots was revealed. As for organ level the evident reduction of morphometric characteristics (weight of leaves and roots, length of root, surface area of leaf) was revealed which can be interpreted as an evidence of xerophytesation increasing the plant’s survivability in hostile environment. The revealed adaptive changes described above form the plant’s resistance to the extreme environmental factors and present an evidence of plant’s ability to fully conduct its vital functions in the conditions of the mining waste.

More information: https://www.e3s-conferences.org/articles/e3sconf/pdf/2018/16/e3sconf_iims2018_02026.pdf

Inhibitory effect of Taraxacum officinale L (Compositae) aqueous root extract on spermatogenesis

Purpose: To investigate if Taraxacum officinale officinale root aqueous extract has anti-spermatogenic activity similar to that of the whole plant which was shown previously to inhibit spermatogenesis.

Methods: Taraxacum officinale aqueous extract was prepared by soaking 100 g of dried materials in 1 L distilled water for two days at 45 oC. Fifty adult male rats were divided into five groups and treated for 60 days. Four groups were gavaged with the whole plant or root aqueous extract in low or high doses. The male rat rats were allowed to mate with female rats. The control group received distilled water. Sperm count, motility and morphology as well as chromatin integrity were evaluated.

Results: Serum testosterone level, sperm parameters, pregnancy rate and average number of fetuses per pregnant females decreased significantly in the treated groups compared to control and in the rootreceiving rats compared to the whole plant-receiving rats. Female rats which were mated with high dose root-receiving males did not deliver fetuses. Cross sections of seminiferous tubules of T. officinaletreated rats showed lesions and disorganized germinal epithelium. Late spermatogenesis maturation arrest (spermatid stage) was observed in all of the treated groups except the high dose root-receiving group which showed early maturation arrest (spermatocyte stage). In addition, the mRNA level of two spermatogonial stem cell markers responsible for self-renewal and proliferation of spermatogonia increased in high dose-receiving rats.

Conclusion: Taraxacum officinale root aqueous extract has inhibitory effects on spermatogenesis. Further studies are required to identify specific ingredient(s) in T. officinale that may be useful as male contraceptive(s).

Keywords: Taraxacum officinale, Dandelion, GDNF family receptor alpha 1, Macrophage ColonyStimulating Factor, Promyelocytic Leukaemia Zinc-Finger, Testosterone, Sperm count

More information: https://www.ajol.info/index.php/tjpr/article/viewFile/150952/140530

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